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These different scales can be used in combination to identify abnormalities or severity of different symptoms which may present in FRDA, and have been used in the clinical trials which tested the compounds discussed in this review paper

The FDA label carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies

Therefore, an ideal vaccine should incorporate additional antigenic components that provoke an immune response early in the infection process, such as surface proteins or polysaccharides (Razim et al., 2023)

MOTS-c safety data comes from animals plus one analog (CB4211) human Phase 1 trial