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32 In this study, inhibition of COX-2 not only restored the damaged mitochondria in hepatocytes and reduced iron concentrations in TAA-treated liver tissue and erastin-treated primary mouse hepatocytes, but also decreased the levels of polyunsaturated fatty acids, including Lin, AA, AdA, and C22:6, and downregulated lipid peroxidation and oxidative stress

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A.BasuP.CohenL.et al (2022)

Absorption from this layer is slower and more gradual, leading to a more sustained release into the bloodstream