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10.1097/ICO.0b013e31821dd986 [DOI] [PMC free article] [PubMed] [Google Scholar] Turkovic B., Sikiric P., Seiwerth S., Mise S., Anic T., Petek M., et al

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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

Moreover, the administration of these peptides to healthy individuals for anti-aging or performance enhancement introduces additional ethical and safety considerations, as the long-term effects of chronic exposure in otherwise healthy populations remain unknown