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Tumor cells showed diffuse and strong expression of HMB45 (Figure 2), Melan A, and S-100 protein but were negative for Cytokeratin, CD56, Chromogranin, Synaptophysin

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The attached gingiva is the most common location, but physiological pigmentation can be noted anywhere in the oral cavity, including the tips of the fungiform papillae on the dorsal tongue and the diagnosis of physiological pigmentation normally is made clinically and do not need any treatment (4)

Bertolotto, C