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Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies
As an engineered analogue, cagrilintide is designed to mimic key receptor-binding properties of native amylin while incorporating structural modifications that extend its activity and stability in experimental systems
