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While DHA-CHO-VE supplementation did not affect bile acid concentrations, it did increase intestinal fibroblast growth factor 19 (FGF19), a key regulator of bile acid synthesis and metabolism (160)
It depends on your goals and history
Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension
20 As such, it would likely act as a mood elevator similar to Effexor