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This amplification of pain signaling within the CNS involves an increased responsiveness of sensory neurons in the spinal cord and higher brain centers to sensory inputs (Woolf, 1983

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Hashimoto T, Volk D, Eggan S, Pierri J, Sun Z, Sampson A, et al
Clinical Evidence Supporting Combined Therapy Diagram from the NADPARK study detailing the design and outcomes of a phase I trial on nicotinamide riboside supplementation in Parkinsons disease
