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Description
Matrix mechanics and regulation of the fibroblast phenotype

Regardless, our finding that expression of mitochondrially-targeted CHAC1 is sufficient to restore ferroptosis sensitivity in CHAC1-deficient cells indicates that the maintenance of matrix cysteine availability is operative in the induction of ferroptosis

Physiology-Cell Physiology 278, C292C302

Therefore, IGF-1 is the crucial factor in serum and synovial fluid that promotes cartilage matrix anabolism