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Chemical cleavage of fusion proteins for high-level production of transmembrane peptides and protein domains containing conserved methionines

The average age of onset was 48.1 years [2765], with a maletofemale ratio of 1:6

We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the substantia nigra, striatum, and cerebral cortex, which eventually surfaces as the hallmark features of PD

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