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5-amino-1mq nnmt inhibition mechanism Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target Frontiers | Nicotinamide N-methyltransferase (NNMT):
Description
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule compound that has attracted interest in metabolic research
5-Amino-1MQ is an oral NNMT (nicotinamide N-methyltransferase) inhibitor that works by blocking an enzyme that depletes cellular NAD+ and SAM
Importantly, methylquinolinium analogues displayed high selectivity, not inhibiting related SAM-dependent methyltransferases or enzymes in the NAD + salvage pathway
5-Amino-1MQ: No established human safety profile exists
