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Primary Handling Editor: Jerome Staal, in collaboration with the Nature Medicine team

The median PFS and median OS for MET-amplified patients was 3.7 and 5.7 months, respectively compared to median PFS and median OS of 2.5 and 12.1 months, respectively, in patients without MET amplification (Jia et al., 2022)

The MG detoxification by these enzymes in case of exogenous MG stress is related directly to their enzymatic properties such as their catalytic efficiency (Kcat/Km ratio)

There are three activities of the MTHFD1 encoded enzyme that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase