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Clinical Translation Roadmap The initial step in implementing individualized diets in SLE is to evaluate nutrient risk using proven instruments like the Mini Nutritional Assessment (MSA) or the Malnutrition Universal Screening Tool (MUST), in addition to culturally relevant nutritional evaluations

doi: 10.1074/jbc.M404747200 34 Institute of Health Metrics and Evaluation (2023)

Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

In the presence of chemicals such as persistent organic pollutants that deplete GSH, contribution to the methionine pathway may be diminished because of greater need to synthesize GSH (numbered boxes on the right)