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Despite weaker affinities to the transporter, tramadol is highly specific to NET/SERT over DAT displaying ~50-fold greater affinity to NET over DAT 56

10.1161/01.hyp.34.1.144 2 AndreadiA.BelliaA.Di DanieleN.MeloniM.LauroR.Della-MorteD.et al (2022)

10.3390/ijms252111338 127 LanzT.CarterD.MerchantK
Through the tonoplast route, plants reduce sodium transport in the shoot by accumulating Na + ions in the root vacuoles (Wakeel et al., 2011)
