glutathione depletion-induced cell death depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer Role of GSH in apoptosis
Description
These ADAs can neutralize the therapeutic efficacy, alter pharmacokinetics, and even cause adverse immune responses
10.1038/cr.2009.117 Cell Res
doi: 10.5555/URI:PII:0022214367900765 48 PandayS.TalrejaR.KavdiaM
Additionally, oxidative stress affects testicular somatic cells and the hypothalamic-pituitary-gonadal (HPG) axis, contributing to lower testosterone levels and diminished spermatogenic output
