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Second, GSNO may help maintain or restore endothelium derived NO signaling, preserving vasorelaxation, minimizing reperfusion-associated vasoconstriction, and supporting coronary perfusion

In addition to MnO2, other transition metal oxides like Co3O4 and CeO2, which can react with GSH, can also be used to design GSH-responsive DDSs [69]

The optimal precursor (NMN vs NR), dose, and duration remain debated

Our studies highlight the ability of kinase inhibitors to modulate the cysteine sulfenome and should find broad application in the rapidly growing field of redox medicine
