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Similarly, prenatal exposure of pregnant C57BL/6J mice to PQ (0.3 mg/Kg) or maneb (1 mg/Kg) altered the development of the nigrostriatal system and enhanced its vulnerability to neurotoxins later in life, which could contribute with the development of PD during aging (Barlow et al., Although there is no direct evidence linking early exposure to environmental pollutants and epigenetic changes with increased susceptibility to LOPD, there is a plausible association based on the following considerations: (1) epigenetic alterations have been observed in PD brains
Buchanan RW, Javitt DC, Marder SR, Schooler NR, Gold JM, McMahon RP
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