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A systematic review found that high magnesium levels were associated with a general decrease in insulin resistance (IR), based on four epidemiological studies in women with polycystic ovary syndrome (PCOS)

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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems