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Although MTHFR does not directly cause B12 deficiency, research suggests that people with the MTFHR C677T mutation have a significantly higher risk of deficiency

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Although cyanocobalamin is more readily absorbed, much of it is excreted through the urine before it can reach the cells Cyanocobalamin vs Hydroxocobalamin In comparison to hydroxocobalamin, cyanocobalamin has a significantly worse absorption rate and storability, which is why today mostly hydroxocobalamin is used in B12 injections
