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N Engl J Med 357(3):266281

ACTL6A, a member of SWI/SNF complex, has been reported to be involved in various cancers, including squamous cell carcinoma 11,14,52 , colon cancer 12 , osteosarcoma 53 , glioma 10,54 , and hepatocellular carcinoma 13

The ability of ALA to penetrate different tissues and convert to DHLA is crucial for its antioxidant and therapeutic effects

This indicates the critical role of other pathways such as inflammation and oxidative stress in the development and progression of hypertension, and underscores the innovative opportunity in the development of selective antioxidants as potential anti-hypertensive therapies
