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The dissociation of the complexes leads to ASK1 activation and prolonged activation of P38 and JNK that cause cell growth arrest by increasing the expression of the CDK inhibitor P21 CIP1 and apoptosis
The activation of protein kinases may lead to the phosphorylation of transcription factors, which are proteins supporting gene expression
By stimulating lipolysis, they assist in maximizing the fat burned during a calorie deficit or workout
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Whalen K.A., Judd S., McCullough M.L., Flanders W.D., Hartman T.J., Bostick R.M
