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Patients should be counselled that sustainable weight management requires comprehensive lifestyle changes, and that injectable supplements are not a substitute for evidence-based interventions

IGF-1 is insensitive to repetitive freeze-thaw cycles [110,111] and displays only minor circadian fluctuations, negating the need for repetitive standardized sampling procedures as is required with GH due to the pulsatile nature of its release and diurnal variation

And it shifts fuel utilization away from glucose and toward stored fat

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