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As noted earlier, IL-6 is often significantly upregulated in the synovial fluid and serum of OA patients

Lvy J, Cacheux W, Bara MA, LHermitte A, Lepage P, Fraudeau M, et al

Twelve day ligature caused a significantly increased evans blue extravasation in the gingivomucosal tissue, histological signs of inflammation, and alveolar bone destruction

10.1016/j.celrep.2019.11.037 58