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Single-cell RNA-sequencing of small intestinal epithelium shows that EEC-subtype-enriched genes encode for key peptides [substance P, glucagon-like peptide 1 (GLP-1), cholecystokinin (CCK), neurotensin, secretin, glucose-dependent insulinotropic polypeptide (GIP), and ghrelin] as well as synthesizing enzymes for signaling amines (e.g

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