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When all three are present simultaneously, the cell receives converging pro-regenerative signals through multiple pathways

Goswami, P., Mathur, J

Here, we discuss about how pathogens have adapted their physiology to actively exploit the metabolic substrates generated by a robust inflammatory response, how they specifically modulate host metabolism to dampen the immune response, and how sensing the metabolic state of the local environment provides important cues to the bacterium regarding both the anatomical site of infection and the immune status of the area

This mechanistic diversity strengthens the growing recognition that treatment strategies extending beyond the CNS, particularly those involving the gut microbiota or peripheral metabolic pathways, may offer complementary therapeutic benefits