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Further, we studied isoprenaline (75 or 150 mg/kg s.c.) myocardial infarction (1 challenge) and reinfarction (isoprenaline at 0 h and 24 h, 2 challenges) in rats (assessed at the end of the subsequent 24 h period)
10.1371/journal.pone.0217170 111 SeminI.NinnemannJ.BondarevaM.GimaevI.KruglovA

As expected, VEGF as positive control had proangiogenic effect, as opposed to negative control Suramin which practically completely inhibited branching ( Fig