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Once glutathionylated, the enzyme can be reverted to its active state via GRXs or TRX, if the S -glutathionylation is resolved by formation of an intramolecular disulfide [77]
In turn, epigenetic modifications in key enzymes in amino acid metabolism induce the malignant transformation of cells (Blanc and Richard, 2018)
Since DFO is membrane impermeable and accumulates in lysosomes 18 , we believe that it protects the cells against ferroptosis by chelating lysosomal iron as described previously 47
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