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First, the escalation timeline may be extended if GI tolerance is a concern

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Asn-Gly (NG), is the most flexible and since it is acidic, it is most prone to deamidation with a half-life around 24 h under physiological conditions (pH 7.4, 37 C)

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Protocol: Reconstitute per the reconstitution guide

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Unlike scleroderma, the disease primarily involved the extremities but spared the face

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