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Additionally, the plasticity of macrophages, which allows them to switch phenotypes in response to environmental changes, poses a challenge for therapeutic interventions aimed at reprogramming them

METHODS We have followed standard methodologies for this systematic review and meta-analysis, including the PRISMA guidelines and the standards of the Cochrane Handbook of Systematic Reviews, 18 , 19 to guarantee the results transparency, validity, and reliability

J.KiddJ

Thus, stress, ROS formation and apoptosis signals can be counterbalanced by pro-oxidant activities, whose efficiency and availability is critical for cell health