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Each approach, whether oral ingestion or injection, presents distinct advantages, and the decision on whether to opt for oral or injectable forms should be guided by the precise objectives and framework of the research

Some authors suggest that impairments within the endogenous opioid system, such as those proposed here, may, over time, lead to the hyperactivation of pain pathways, and, therefore, transform normal stimuli into painful or heightened responses toward typical pain stimuli (allodynia and hyperalgesia, respectively) [137]

2023;19:e080373

(2) Whole protein peptides: These peptides are derived from full-length self-proteins and can induce a broader immune response against multiple epitopes of the protein