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High therapeutic dosages, frequent administration, significant presystemic metabolism (first-pass effect), enzymatic breakdown, organ toxicity, and limited brain availability owing to the blood-brain barrier (BBB) are some of the challenges that these therapies face [9]
This is consistent across the GLP-1 class semaglutide and tirzepatide users report the same pattern
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APS-NP: p = 0.400)
