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To further investigate the effects of R001 on intracellular STAT3 signaling, we next treated the TNBC cells, MDA-MB-468 and MDA-MB-231, which harbor constitutively active STAT3 with increasing concentrations of R001 for 3 h or a single concentration, 2.5 or 5 M for up to 24 h, and prepared whole-cell lysates for immunoblotting analysis

It is also found that the expression of GDH2 is regulated by the concurrent action of Gcn4 and Gln3 [48]

(iii) Glutathione conjugation of alpha , beta -unsaturated ketones Twenty-six of the substances in this group are alpha , beta- unsaturated ketones (Nos 11241139, 11471149) or alcohols (Nos 1140, 1141, 11501154), which can be oxidized to alpha , beta -unsaturated ketones

Utilizing CRISPR-based functional genomics can systematically identify metabolic enzymes and pathways essential for AML survival and proliferation, offering new therapeutic targets