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Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736, Pliva), is effective in the healing of colocutaneous fistulas in rats: the role of NO-system

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The half-lives derived demonstrated the longest half-life for Albu-LiTE-HB ( t 37.2 h), which was more than 60-fold longer than that of LiTE ( t 0.59 h), and 2-fold longer than that of the NB-containing LiTE variant ( t 18.68 h)

It lies in the activation of Na + channels to depolarize the plasma membrane, or in the activation of K + channels to hyperpolarize it, which is further regulated by the increase and decrease of cAMP, respectively (54, 55)