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[11] They correspond to classical classes C, A, B2, F, and B
While it was shown that GDF8 and GDF11 signal through similar receptors, a direct rigorous comparison of the ligands had not been performed until we published a study demonstrating that GDF8 and GDF11 have significant differences in their signaling properties in multiple cell lines, showing that GDF11 is much more potent than GDF8
As a result, Sermorelin seems to be useful for keeping healthy bones with aging
doi: 10.1016/j.canlet.2017.12.025
