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The accumulation of these metabolites in mutant muscles further supports the notion of altered OXPHOS, which is compensated by increased glycolysis

CVS is also described in 6 of 11 individuals with a pathogenic protein-truncating variant in CHAMP1 (Levy et al., 2022)

Study #2: The effect of combined supplementation of carbohydrates and creatine on anaerobic performance On the other hand, this study concluded that ingesting creatine in combination with large amounts of simple sugars is no more beneficial to anaerobic performance compared to ingesting creatine on its own

doi: 10.3389/fphar.2024.1345522 54 PatelDMenonDBernfeldEMrozVKalanSLoayzaDet al