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Description
The presence of NiO NPs amplified the cytotoxic effects of aged -synuclein amyloid protein by promoting the production of high levels of ROS, inactivating SOD and catalase, and inducing inflammation, as evidenced by elevated levels of tumor necrosis factor-alpha (TNF-), IL-1, and IL-1

Nature 623 , 283291 (2023)
Vpr induces oxidative stress by stabilizing p53 protein, increasing transforming growth factor-beta protein levels and ROS production, and suppressing antioxidant enzymes 118,119,120

As we go through life, the color of the skin becomes uneven