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Description
After exposure to oxidative stimuli, Nrf2 dissociates from Keap1, its negative regulator, and translocates into the nucleus where it heterodimerizes with small Maf proteins [77] and binds to antioxidant responsive element (ARE) sequences, triggering a cytoprotective adaptative response
Nutrients 17 (5), 794
Since the system is closely related to the machinery for building fatty acids and polyketides, hybrid compounds are often found
doi: 10.1016/j.freeradbiomed.2007.02.015
