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These manifestations occurred at a mean age of ~60 years, and progressed towards the appearance of a pseudobulbar palsy (a syndrome characterized by slurred speech, dysarthria, dysphagia and emotional lability, which is caused by bilateral lesions of corticobulbar pyramidal tracts), a step-by-step walk (marche petits pas), cognitive decline, dementia and premature death

Thus, we recommend to regularly assess cognitive function among PwPD, test Vit B12 serum levels along with Hcy and MMA levels

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A recent study analyzed the circulating microbiome of patients with alcoholic hepatitis, and found a decrease in Bacteroidetes and an enrichment of Fusobacteria