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Furthermore, both cross-sectional and prospective studies detected a significant correlation between Cd levels in blood and/or urine and the development of atherosclerosis (131)

Glutathione system The glutathione (GSH) system is a major thiol-based defense system against oxidative and electrophilic stress in mammals and functions as co-substrate for the GPxs, which efficiently remove H 2 O 2 thereby preventing oxidative insults and influencing together with glutaredoxin (Grx) the redox state of proteins via reversible S-glutathionylation [97]

This tight network collaborates to restrict large molecules from entering by the paracellular route

Materials and methods The experimental animals were divided into 3 groups of 8 rats