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There are multiple mechanisms that are involved in activating Nrf2, including interaction with cysteine residues on Keap1, disruption of Nrf2/Keap1 interaction, epigenetic modification and activation of protein kinases

Notably, EVs extracted from ACE2-expressing cells have been nebulized as ACE2 decoys 51,52,53,54

doi: 10.2215/cjn.04010609 18 TabatabaiNMSharmaMBlumenthalSSPeteringDH
