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Duration of melasma ranged from 2-10 years with a meanSD of 5.72.51 years

2.1.4 Outcome Here, we included the following: neurochemical damage, neurobehavioral impairment, monoamine and metabolite levels, histochemistry, HPLC assay, lipid peroxidase, immunohistochemistry, Western blot assays, RT-PCR, CSF markers, acetylcholinesterase, butyrylcholinesterase, neuroprotective markers, antioxidant levels, oxidative markers, apoptotic markers, histopathology of the brain, immunofluorescence assays, and mitochondrial assays

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Among mycotoxins, AFs are particularly concerning as they are highly toxic and considered as Group 1 human carcinogens by the International Agency for Research on Cancer (IARC) [10,11]