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Furthermore, while GABAAR currents are increased by barbiturates (and other general anesthetics), barbiturates, as relatively non-selective compounds, bind to an entire superfamily of ligand-gated ion channels and can block ligand-gated ion channels predominantly permeable for cationic ions, the neuronal nicotinic acetylcholine receptor (nAChR), the 5-HT3 receptor, the glycine receptor, and others [231,232]

Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders

Real-time PCR analysis showed a high expression in the liver and a much lower expression (approximately -10 5 ) in the cervical spinal cord, cerebral cortex, lung, duodenum, stomach, spleen, kidney, skeletal muscle, and bladder [158]

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