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Supporting this model, transcriptomic analysis of 3xTg-AD mice at different disease stages (2, 10, and 20 months) revealed age-related increases in DAM-associated genes such as Trem2, Tyrobp, Clec7a , and Cd68 , particularly in aged AD mice compared to young AD mice and aged-wild-type controls (Lambracht-Washington et al., 2023)

This may be related to its ability to reduce mitochondrial oxidative stress in posterior lung cells after COVID-19 infection while conferring a general antioxidant effect (142)

Mughal S, Faizy R, Saadabadi A (2020) Autism spectrum disorder

Under neutral pH (shown in a blue box), the intermediate is metabolized to a general isothiocyanate or to indole-3-carbinol or oxazolidine-2-thione via the unstable intermediates, indol-3-ylmethyl-isothiocyanate or -OH-isothiocyanate, respectively