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[PMC free article: PMC4848993] [PubMed: 27070596] (Listing of published cases of liver injury from HDS products, but does not list those attributed to kava)

doi: 10.1016/s0378-4274(00)00285-x

Herein we demonstrate that IL-1 creates a pro-arrhythmic environment both in rodent and human cells by reducing the repolarizing K + current (I to ), by increasing CaMKII oxidation/ phosphorylation and Ca 2+ spark frequency

All methods involving human material were carried out in accordance with the Declaration of Helsinki guidelines and regulations
