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In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione

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Further, we observe greater number of changes to protein abundance and phosphorylation when NQO1 is increased compared to when NQO1 is low (Supplementary Figure 34 and Figure 2)