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This phenomenon, known in medical literature as the "Folate Trap", creates a functional deficiency where the cell starves for active folate even if there is plenty of it circulating in the blood (though the cited source actually discusses the nutritional value of plant-based diets in relation to human amino acid requirements)

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Additional research is needed to elucidate the mechanisms that control holo-TC homeostasis in the normal population and in pathologies that alter vitamin B 12 transport and utilization

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