glutathione and environmental toxins GSTM1: GST Enzymes for Deficient Glutathione in the Pathophysiology

The advent of high-content and high-throughput screening technologies has accelerated the discovery of cell-intrinsic and cell-extrinsic pathways that may be targeted to prevent or reverse cisplatin resistance in cancer patients

Many patients exhibit: Heat sensitivity Stress-triggered flushing Rapid redness changes Burning sensations This suggests dysregulation involving: Mast cells Nervous system signaling Blood vessel reactivity Stress, poor sleep, and cortisol dysregulation may amplify these pathways

Stabler, S

Molecular Docking Analysis The binding of GSH to its core targets including the epidermal growth factor receptor (EGFR), prostaglandin-endoperoxide synthase 2 (PTGS2), and hypoxia inducible factor 1 subunit alpha (HIF1A) was studied by molecular docking