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Description
We examined the intact A-D LBD dimer of the partially ruptured structure and noted that, while the general orientation is similar to that seen in the fully intact state, a re-shaping of the dimer interface occurs, which includes tightening along the D2-D2 surface and a ~ 5 inter-subunit rotation (Fig
Overall, as a new-generation SIRT1 agonists, SRT2104 has significant advantages in specificity, pharmacokinetics, and clinical efficacy
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Diabetologia (1977) 13:99104
