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Significantly decreased GSH content in tumor cells in the glutamine-supplemented group correlates with enhanced tumor volume loss.[76] These data suggest that oral glutamine supplementation will enhance the selectivity of antitumor drugs by protecting normal tissues from and possibly sensitizing tumor cells to radiation-induced and chemotherapy treatment-related injury.[77,76] EFFECT OF GLUTAMINE ON METHOTREXATE EFFICACY AND TOXICITY Oral glutamine has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect

if these vitamins are missing, homocysteine cannot be further utilised and gets stuck in a dead end

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