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In addition, MSNs have also been used to locally deliver immune checkpoint inhibitors or cytokines to the tumor environment, enhancing antitumor immunity
Floris Wuyts explaining why MdDS occurs

The CCI score is based on a number of conditions, including previous myocardial infarction, stroke, and liver disease, that are each assigned different weights, with a higher weight representing more severe morbidity

doi: 10.1161/CIRCRESAHA.115.306427
