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increasing glutathione peroxidase Figure 1 from Comparing and glutathione reductase activity and their associations with cardiovascular measures in Africans and Caucasians : the SABPA study Simplified catalytic mechanism of the
Description
Ferrostatin-1 potently inhibits the release of high mobility group box protein (HMGB)-1, a classical marker of necroinflammatory response, in cell models and human skin explants after UVB irradiation, thus confirming that ferroptosis is a key element of the necroinflammatory process in keratinocytes

NRF2 transcription factor is also implicated in the regulation of the GSH biosynthesis genes (GCLC, GCLM)

BMC Biol 10:26

van den Heuvel MP, Sporns O
